Mixed Connective Tissue Disease

Clinical presentation features an overlap syndrome combining characteristics of Systemic Lupus Erythematosus (SLE), Systemic Sclerosis (Scleroderma), and Polymyositis.

Raynaud phenomenon is the most common initial clinical manifestation, often preceding other systemic symptoms by years.

Swollen, puffy fingers (sausage-like digits) are a classic, highly characteristic physical exam finding in patients with this condition.

Patients frequently exhibit inflammatory myositis characterized by proximal muscle weakness and elevated creatine kinase (CK) levels.

Pulmonary hypertension is the most serious and common cause of mortality in patients with long-standing disease.

Treatment for mild disease involves hydroxychloroquine or NSAIDs, while severe organ-threatening involvement requires systemic corticosteroids or immunosuppressants.